Fig. 7.

M1 macrophage exosomal miR-326 reduces the volume and weight of HCC tumor in vivo. a–c The effect of transfection of miR-326 mimic on the tumor volume and tumor of nude mice xenografted with HepG2 cells. d–f The effect of transfection of miR-326 inhibitor on the tumor volume and tumors of nude mice xenografted with SMMC-7721 cells. g–i The effect of co-culture with miR-326 mimic-transfected M1 macrophage-derived exosomes on the tumor volume and tumor of nude mice xenografted with HepG2 cells. j–l The effect of co-culture with miR-326 inhibitor-transfected M1 macrophage-derived exosomes on the tumor volume and tumor of nude mice xenografted with SMMC-7721 cells. In panel b and c, *P < 0.05 versus the NC-mimic group; In panel e and f, *P < 0.05 versus the NC-inhibitor group; In panel h and i, *P < 0.05 versus the control group, #P < 0.05 versus the Exo-NC-mimic group; In panel k and l, *P < 0.05 versus the control group, #P < 0.05 versus the Exo-NC-inhibitor group. Measurement data were depicted as mean ± standard deviation (n = 5), comparisons among multiple groups were conducted by one-way analysis of variance