TABLE 3.

The different features between iN and iPSCs-derived neurons.

Features	iN	iPSCs-derived neurons
Epigenetics reset	The generation of iN will not reset epigenetic information	Neuron derived from iPSCs will reset epigenetic information
Cell number and maintain	iN cell number is limited by original cell number and reprogramming efficiency, which are uneasy to maintain.	After acquisition of iPSCs, the production of neurons can be unlimited, which are easy to maintain.
Time for acquiring mature neurons	Directly reprogramming somatic cells to neurons only takes several weeks	Obtaining neurons derived from iPSCs will takes several months depending on protocol
Technical Challenges	Generation of iN using direct reprogramming technology is much simpler	iPSC technology of generation iN is complicated
Original cell types	Based on technology, the source for iN is limited (fibroblasts ect.)	The source for iPSCs is variable (fibroblasts, adipose stromal cells ect.)