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. 2020 Nov 19;8:580814. doi: 10.3389/fcell.2020.580814

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Copyright © 2020 Wang, Bharti and Levental.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Lipid domains are present on membrane systems, including not only the PM of mammalian cells but also many organellular membranes [endoplasmic reticulum (ER), Golgi, endosomes, lysosomes, lipid droplets (LDs)], viral membranes, and cell-secreted membrane structures like lung surfactants and milk fat globule membranes (MFGMs). Green color represents ordered domains (either liquid or solid). Other abbreviations: TGN, trans-Golgi network; TG, triglyceride; TMD, transmembrane domain; GPI-AP, GPI-anchored protein; FA, fatty acid.