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Study schematic. ∗Serum creatinine (Scr) must be captured twice prior to surgery and after paitent goes off cardiopulmonary bypass (CPB). A sample for SCr must be obtained after the patient goes off CPB and before the first administration of the study drug, then at 12 ± 2 hours, at 24 hours ± 2 hours, and at 48 ± 2 hours after the patient has gone off CPB. PK, pharmacokinetics.
