Figure 4.

Visits in which patients showed hypocalcemia (corrected Ca level < 8.3 mg/dL) and 95% confidence intervals, based on a binomial distribution for each treatment group. (a) Comparison of etelcalcetide patients versus controls. (b) Etelcalcetide users corrected hypocalcemia by active vitamin D (Vit D) versus oral calcium preparation (Ca). The adjusted mean serum corrected calcium levels and 95% confidence interval calculated by a linear mixed model with each treatment group, time-point, and interaction of treatment group and time-point as fixed effects. Changes of each index compared among treatment groups at each time-point using the Tukey-Kramer method to correct for multiplicity. (c) Comparison of etelcalcetide patients versus controls, (d) Etelcalcetide users corrected hypocalcemia by active vitamin D (Vit D) versus oral calcium preparation (Ca). ∗P < 0.05. VitD, vitamin D.