Adjusted mean phosphate levels and 95% confidence intervals (a, b) and calcium-phosphate products and the 95% confidence intervals (c, d) calculated using a linear mixed model with each treatment group, time-point, and interaction of treatment group and time-point as fixed effects. Changes in each index are compared among treatment groups at each time-point using the Tukey-Kramer method to correct for multiplicity. (a, c) Comparison of etelcalcetide patients versus controls. (b, d) Etelcalcetide users corrected hypocalcemia by active vitamin D (Vit D) versus oral calcium preparation (Ca). ∗P < 0.05. VitD, vitamin D.