Table 1.

Summary of histologic findings in glomeruli of patients with C3 glomerulopathy^a

Light microscopy	Electron microscopy	Immunofluorescence
•Mesangioproliferative, membranoproliferative, and/or endocapillary proliferative •With or without crescents •Rarely, can have normal-appearing glomeruli on light microscopy	•Many cases will have electron-dense deposits •When deposits are intramembranous, the disease is classified as dense deposit disease (DDD) •When dense deposits are found in a pattern that does not meet criteria for DDD, the disease is classified as C3 glomerulonephritis.	•Staining for C3 is seen in the glomeruli •Immunofluorescence for C3 is at least 2 orders of magnitude more than any other immune reactant

^aBased on consensus criteria.^1,17