Table 4.
Biochemical parameters for the combined KidCOM and C3 Glomerulopathy and Membranoproliferative Glomerulonephritis: Pediatric Outcomes cohorts
| Clinical parameters | Total cohort (N = 165) | IC-MPGN (n = 42) | C3G (n = 43) | P value (IC-MPGN vs. C3G) |
|---|---|---|---|---|
| Cr at diagnosis (μmol/l) | 148.6 (107.5–189.8) | 93.7 (70.7–116.6) | 168.9 (45.4–292.4) | NS (0.2528) |
| Cr at last follow-up (umol/l) | 132.2 (77.4–186.9) | 99.1 (46.3–151.9) | 145.0 (−8.1 to 298.1) | NS (0.4669) |
| P value | NS (0.6382) | NS (0.8389) | NS (0.8097) | |
| eGFR at diagnosis (ml/min per 1.73 m2) | 71.6 (63.0–80.3) | 76.0 (62.6–89.5) | 82.8 (67.5–98.2) | NS (0.4112) |
| eGFR at last follow-up (ml/min per 1.73 m2) | 94.6 (86.1–103.0) | 93.4 (80.8–106.2) | 108.7 (93.3–124.0) | NS (0.3237) |
| P value | <0.0001a | 0.0315a | 0.0134a | |
| Delta eGFR (ml/min per 1.73 m2) | 22.9 (13.1–32.7) | 17.4 (1.7–33.2) | 25.8 (5.7–45.9) | NS (0.5200) |
| Albumin at diagnosis (g/l) | 28 (26–30) | 27 (23–31) | 27 (24–30) | NS (0.4510) |
| Albumin at last follow-up (g/l) | 38 (36–39) | 35 (31–38) | 39 (37–41) | 0.0226a |
| P value | <0.0001a | 0.0033a | <0.0001a | |
| C3 at diagnosis (g/l) | 0.38 (0.30–0.46) | 0.26 (0.16–0.36) | 0.39 (0.19–0.59) | NS (0.71) |
| C3 at last follow-up (g/l) | 0.71 (0.61–0.81) | 0.50 (0.30–0.70) | 0.82 (0.63–1.0) | 0.0141a |
| P value | <0.0001a | 0.0066a | 0.0003a | |
| Delta C3 (g/l) | 0.33 (0.24–0.42) | 0.24 (0.07–0.40) | 0.43 (0.22–0.64) | NS (0.1485) |
| C4 at diagnosis (g/l) | 0.22 (0.17–0.27) | 0.21 (0.14–0.27) | 0.25 (0.10–0.40) | NS (0.6937) |
| C4 at last follow-up (g/l) | 0.22 (0.19–0.25) | 0.22 (0.18–0.32) | 0.21 (0.16–0.25) | NS (0.5284) |
| P value | NS (0.9733) | NS (0.8054) | NS (0.5105) | |
| Urine protein/creatinine ratio at diagnosis (mg/mmol) | 338.4 (222.2–454.6) | 460.3 (204.6–716.0) | 395.6 (160.7–630.5) | NS (0.5297) |
| Urine protein/creatinine ratio at last follow-up (mg/mmol) | 253.8 (91.9–415.7) | 207.9 (49.7–366.0) | 117.9 (52.1–183.7) | NS (0.2067) |
| P value | NS (0.4289) | NS (0.1170) | 0.0267a |
C3, serum C3 level (reference range 0.83–1.52 g/l); C4, serum C4 level (reference range 0.13–0.37 g/l); C3G, C3 glomerulopathy; Cr, serum creatinine; eGFR, estimated glomerular filtration rate; IC-MPGN, immune-complex membranoproliferative glomerulonephritis; NS, not significant.
Numeric data shown as the mean with 95% confidence interval.
a
Statistically significant.