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. 2020 Nov 19;11:577561. doi: 10.3389/fpsyt.2020.577561

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Copyright © 2020 Park, Shim and Shim.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The number of IL-1β immunostained nuclei in the paraventricular nucleus (A) and motor trigeminal nucleus regions (B). The naïve normal group (NOR), a surgically ovariectomized group (OVX), the only stressed group (ST), and the OVX and stressed group (OVX + ST). Each group contained six rats (n = 6). The results of IL-4 reactivity were analyzed by performing separate one-way ANOVA on the number of the IL-4 immunostained neurons among the groups. Each value represents the mean ± S.E.M. *p < 0.05 compared to the normal group. ⁺⁺p < 0.01 compared to the ST group. Photographs showing the distribution of IL-4 immunoreactive cells in the brain of normal group (C,F), OVX (D,G), and OVX + ST (E,H). Sections were cut coronally at 30 μm and the scale bar represents 200 μm. PVN, paraventricular nucleus; MTN, motor trigeminal nucleus.