Figure 6.

IL-6 alone recapitulates the entire phenotype of Mdr2^−/− mice with regard to the control of parasite infection. (A) Schematic representation of the experimental procedure. Six-week-old WT FVB mice (n = 6) were treated with recombinant murine IL-6 (rmIL-6) and infected with 10⁴ PbANKA SPZs. The same mice were challenged with 10⁴ and 5 × 10⁴ PbANKA SPZs at days 10 and 18 p.i. Non-treated six week-old WT FVB mice (n = 6 per group) were infected and used as controls for D10 and D18 challenges. Parasitemia (B) and Survival rate was recorded over time (Kaplan–Meier survival rates, Mantel–Cox test **0.0013 < p < 0.0053) (C). Data are representative of three independent experiments.