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. 2020 Nov 19;11:606811. doi: 10.3389/fphys.2020.606811

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Copyright © 2020 Mohsin, Souza, Aliabadi, Worker, Cooper, Afrin, Murata, Xiong and Feng Earley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Increased PRR immunoreactivity in the PVN of the hypertensive human brain. (A,B) Representative images of PVN tissues from a normotensive (NTN) human brain and a hypertensive (HTN) human brain immunolabeled for the PRR. (C) Representative image of PVN tissue immunolabeled with rabbit pre-immune serum. (D) Significant difference in the relative intensity of PRR immunoreactivity in NTN and HTN groups in the PVN. (E) The relative intensity of PRR immunoreactivity in NTN and HTN groups in lateral PVN region. (F) The background relative intensity for NTN, HTN groups, and the negative control. (N = 7) and NTN (N = 4) subjects; ^* p < 0.05 vs. NTN by two-tailed, unpaired Student’s t-test.