TABLE 1.

The identified WNT10A variants in subjects with tooth agenesis or peg-shaped upper lateral incisors.

Family	Patient	Dental arch	Tooth
			8	7	6	5	4	3	2	1	1	2	3	4	5	6	7	8	Number of missing teeth (excluding 3rd molars)	Mode	Mutation	Amino acid change
1	Patient 1	Upper				•	•		□			□		•	•
		Lower			•	•	•							•	•		x		9	Het	c.916_918dup	p.Asn360dup
2	Patient 2	Upper				•	•							•	•
		Lower	•															•	6 (4)	Het	c.637G > A	p.Gly213Ser
3	Patient 3	Upper	•			•	•	•						•	•			•
		Lower	•			•								•	•			•	12 (8)	Homo	c.637G > A	p.Gly213Ser
	Patient 3’s older sister	Upper				•									•
		Lower	□			□								□	□			□	2	Het	c.637G > A	p.Gly213Ser
4	Patient 4	Upper							□			□
		Lower				•									•				2	Het	c.511C > T	p.Arg171Cys
5	Patient 5a	Upper	•			•			■			■						•
	(II.3)	Lower	•			•												•	8 (4)	Homo	c.511C > T	p.Arg171Cys
	Patient 5’s sister	Upper							■			■
	(II.2)	Lower	■			□												•	4 (2)	Het	c.511C > T	p.Arg171Cys
	Patient 5’s mother	Upper							□			□
	(I.2)	Lower																	0	Het	c.511C > T	p.Arg171Cys

1, central incisor; 2, lateral incisor; 3, canine; 4, first premolar; 5, second premolar; 6, first molar; 7, second molar; 8, third molar.; •, missing tooth; ■, missing upper lateral incisor; □, peg-shaped upper lateral incisors; x, extraction; NA, not available; Het, heterozygous; Homo, homozygous.^aThe heterozygous missense variant, c.413A > T (p.Asn138Ile), in EDARADD was also found in Patient 5.