Table 1.

National Hearts in Rhythm Organization (HiRO) Registry inclusion and exclusion criteria

HiRO Registry inclusion criteria

HiRO Registry exclusion criteria

Inherited arrhythmias (IA): long QT syndrome (LQT), short QT syndrome (SQT), catecholaminergic polymorphic ventricular tachycardia (CPVT), Brugada (BrS), arrhythmogenic right ventricular cardiomyopathy (ARVC), familial cardiac conduction disease (FCCD) Inherited cardiomyopathies (ICM): hypertrophic cardiomyopathy (HCM), Mendelian dilated cardiomyopathy (DCM) including lamin and phosopholambin (LMNA and PLN), and left ventricular noncompaction (LVNC) Unexplained cardiac arrest syndromes: including early repolarization (ER), idiopathic ventricular fibrillation (IVF), short coupled IVF (SCIF), polymorphic ventricular tachycardia not otherwise diagnosed (PMVT, NYD), sudden arrhythmic death syndromes (SADS), and malignant mitral valve prolapse (MVP) Deceased cases of sudden cardiac death: suspicious for an inherited arrhythmia/cardiomyopathy condition Carriers of a pathogenic or likely-pathogenic variant in an IA- or ICM-related gene not otherwise meeting criteria Unaffected first- and second-degree relatives of anyone meeting the above criteria

Known sarcoidosis Mitral valve prolapse unless unexplained cardiac arrest or syncope with documented PMVT Heart failure/nonfamilial dilated cardiomyopathy without a positive family history of affected FDRs or SDRs Aortopathies including Marfan syndrome, Ehlers Danlos, familial thoracic aortic aneurysm, and dissection Neuromuscular disease Familial hypercholesterolemia

FDR, first-degree relative; SDR, second-degree relative.