Table 5.
Group hubs, defined as top 20% of nodes based on composite hub score for symptomatic patients with and without bvFTD.
| C9+ bvFTD+ (n = 9) | C9+ ALS-only (n = 9) | ||
|---|---|---|---|
| VOI | Zcomposite | VOI | Zcomposite |
| L Posterior cingulate cortex | 9.512 | R Superior temporal gyrus | 8.346 |
| L Superior temporal gyrus | 7.121 | R Lingual gyrus | 7.159 |
| R Superior frontal gyrus | 6.652 | R Middle temporal gyrus | 6.744 |
| L Superior frontal gyrus | 6.437 | L Middle temporal gyrus | 6.483 |
| L Putamen | 6.391 | L Superior temporal gyrus | 5.412 |
| R Superior temporal gyrus | 5.528 | R Caudate | 5.135 |
| R Fusiform gyrus | 5.102 | R Banks STS | 4.803 |
| R Thalamus | 5.022 | R Inferior parietal cortex | 4.639 |
| L Thalamus | 4.732 | R Superior frontal gyrus | 4.535 |
| R Lingual gyrus | 4.629 | R Precentral gyrus | 4.425 |
| R Lateral occipital cortex | 4.124 | L Lingual gyrus | 4.330 |
| L Pericalcarine cortex | 4.069 | R Caudal anterior cingulate cortex | 3.925 |
| L Inferior temporal gyrus | 3.797 | L Superior frontal gyrus | 3.862 |
| R Middle temporal gyrus | 3.732 | R Isthmus of the cingulate cortex | 3.810 |
| R Inferior parietal cortex | 3.728 | R Inferior temporal gyrus | 3.734 |
| R Hippocampus | 3.626 | L Precentral gyrus | 3.596 |
L, left, R, right; shared hubs shown in bold; hubs where the same contralateral region is a hub shown in italics; hubs that were not highly ranked in the comparison group are underlined. Zcomposite is the composite score of each node's Z scores in the five hub measures described above.