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. 2020 Nov 19;14:592797. doi: 10.3389/fnana.2020.592797

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Copyright © 2020 Pérez-Villegas, Pérez-Rodríguez, Negrete-Díaz, Ruiz, Rosa, de Toledo, Rodríguez-Moreno and Armengol.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Panels (A,B) illustrate the transmission electron mosaic microphotographs used for the quantitative analysis. The only signs of degeneration within presynaptic terminals were counted, as described in the preceding figure (Figures 10C,D). No differences were found in the number of presynaptic terminals between the control and tbl CA1 (C, p = 0.1027245). However, there were significant differences in the signs of degeneration in the tbl CA1 presynaptic endings (D, ***p = 0.000014), as well as in the presynaptic endings with degenerative signs/synapses ratio (E, *** p = 0.0000008) relative to the control CA1.