Table 1.
Clinical, demographic and laboratory data of the patients in the training set stratified according to 6-month favorable or unfavorable outcome after acute ischemic stroke.
| Favorable outcome (mRS 0–2) | Unfavorable outcome (mRS 3–6) | P-value | |
|---|---|---|---|
| Patients, n | 955 | 433 | |
| Age, years, median (IQR) | 66 (58–74) | 77 (68–83) | <0.0001#* |
| Sex, n (%) | <0.0001* | ||
| Male | 682 (71.4) | 254 (58.7) | |
| Female | 273 (28.6) | 179 (41.3) | |
| Onset-to-admission delay <4.5 h, n (%) | 236 (24.7) | 127 (29.3) | 0.070* |
| Medical history, n (%) | |||
| Hypertension | 650 (68.1) | 317 (73.2) | 0.053* |
| Diabetes mellitus | 248 (26.0) | 143 (33.0) | 0.007* |
| Hyperlipidemia | 29 (3.0) | 6 (1.4) | 0.069* |
| Coronary artery disease | 100 (10.5) | 77 (17.8) | <0.0001* |
| Atrial fibrillation | 75 (7.9) | 95 (21.9) | <0.0001* |
| Previous cerebral infarction | 123 (12.9) | 102 (23.6) | <0.0001* |
| Valvular heart disease | 13 (1.4) | 8 (1.8) | 0.492 |
| Smoking, n (%) | <0.0001* | ||
| Never smoker | 394 (41.3) | 255 (58.9) | |
| Former smoker | 129 (13.5) | 66 (15.2) | |
| Current smoker | 432 (45.2) | 112 (25.9) | |
| Drinking, n (%) | <0.0001* | ||
| Never drinker | 525 (55.0) | 307 (70.9) | |
| Former drinker | 84 (8.8) | 47 (10.9) | |
| Current drinker | 346 (36.2) | 79 (18.2) | |
| Baseline data | |||
| Premorbid mRS, median (IQR) | 0 (0–0) | 0 (0–2) | <0.0001#* |
| NIHSS at admission, median (IQR) | 3 (2–5) | 10 (5–16) | <0.0001#* |
| BMI, kg/m2, median (IQR) | 24.38 (22.38–26.64) | 24.03 (21.60–26.37) | 0.046#* |
| Pulse, times/min, median (IQR) | 76 (70–80) | 76 (70–84) | 0.005#* |
| Systolic BP, mmHg, median (IQR) | 140 (130–160) | 142 (130–160) | 0.350# |
| Diastolic BP, mmHg, median (IQR) | 84 (80–94) | 83 (78–95) | 0.533# |
| Platelet count, 109/L, median (IQR) | 195 (159–234) | 188 (150–238) | 0.159# |
| Urea nitrogen, mmol/L, median (IQR) | 5.23 (4.4–6.34) | 6.12 (4.71–7.75) | <0.0001#* |
| Creatinine, μmol/L, median (IQR) | 71 (59–83) | 76 (62–97) | <0.0001#* |
| FBG, mmol/L, median (IQR) | 5.08 (4.50–6.21) | 6.40 (5.05–7.99) | <0.0001#* |
| TC, mmol/L, median (IQR) | 4.41 (3.76–5.16) | 4.41 (3.64–5.18) | 0.574# |
| TG, mmol/L, median (IQR) | 1.31 (0.96–1.86) | 1.18 (0.84–1.59) | <0.0001#* |
| LDL, mmol/l, median (IQR) | 2.71 (2.13–3.31) | 2.76 (1.96–3.27) | 0.470# |
| HDL, mmol/l, median (IQR) | 1.05 (0.9–1.23) | 1.08 (0.9–1.26) | 0.165# |
| Endovascular therapy, n (%) | 72 (7.5) | 55 (12.7) | 0.002* |
| IV thrombolysis, n (%) | 208 (21.8) | 119 (27.5) | 0.020* |
mRS, modified Rankin Scale; IQR, interquartile range; NIHSS, National Institute of Health stroke scale; BMI, body mass index; BP, blood pressure; FBG, fasting blood glucose; TC, total cholesterol; TG, triglyceride; LDL, low-density lipoprotein; HDL, high-density lipoprotein; IV, intravenous.
#
calculated using Mann-Whitney U-test.
*
included into the multiple logistic regression models (P < 0.1).