Risk of Bias for studies of Second-generation Colon Capsule Endoscopy (QUADAS-2) .

Author, Year	Risk of Bias
	Patient Selection	Index Test	Reference Standard	Flow and Timing
Eliakim (2009)	High a	Low	Low	High b
Spada (2011)	High a	Low	Low	High b
Hagel (2014)	High a	Low	Low	High b
Holleran (2014)	Low	Low	Low	Low
Rex (201)	Unclear	Low	Low	High b
Morgan (2016)	Unclear	Low	Low	High b
Igawa (2017)	Low	Low	Low	High b
Parodi (2018)	Low	Low	Low	Low

Abbreviations: QUADAS-2, Quality Assessment of Diagnostic Accuracy Studies.

^aPatients were not selected randomly or consecutively.

^bNot all patients were included in the analysis.