Table 4.
Human SDR-HSDs and their substrates/reactions.
| Gene | Alternative protein names | Substrates | Reaction | Refs. |
|---|---|---|---|---|
| HSD3B1 | Type 1 3β-HSD/Δ5-4 isomerase/SDR11E1 | 3β-Hydroxy-Δ5-sterols | Oxidation & isomerization | (276, 277), |
| HSD3B2 | Type 2 3β-HSD/Δ5-4 isomerase/SDR11E2 | 3β-Hydroxy-Δ5-sterols | Oxidation & isomerization | (277, 278), |
| HSD3B7 | Type 7 3β-HSD/SDR11E3 | 3β-Hydroxy-Δ5-sterols | Oxidation & isomerization | (279) |
| HSD11B1 | Type 1 11β-HSD/Corticosteroid 11β-dehydrogenase isozyme 1/SDR26C1 | 11β-Hydroxysterols (e.g. cortisol), | Oxidation | (280) |
| HSD11B2 | Type 2 11β-HSD/Corticosteroid 11β-dehydrogenase isozyme 2/SDR9C3 | 11β-Hydroxysterols (e.g. cortisol), | Oxidation | (280) |
| HSD17B1 | Type 1 17β-HSD/Estradiol 17β-dehydrogenase 1/SDR28C1 | Estrogens and androgens | Reduction | (281, 282) |
| HSD17B4 | Type 4 17β-HSD/Peroxisomal multifunctional enzyme type 2/SDR8C1 | (24R,25R)-3α,7α,12α,24-Tetrahydroxy-5β-cholestan-26-oyl-CoA | Reduction | (283) |
| HSD17B7 | Type 7 17β-HSD/3-Ketosteroid reductase/SDR37C1 | 3β-Hydroxysterols, 17β-estradiol | Reduction | (284, 285) |