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. 2020 Nov 19;11:575451. doi: 10.3389/fimmu.2020.575451

Figure 2.

Figure 2

Prophylactic OM-MOG prevents the development of spinal cord neuropathology during MOG-EAE in DR2b.Ab° mice. Neuropathological analysis of spinal cord sections from prophylactic vehicle- (upper and middle panels) and OM-MOG-injected (lower panels) DR2b.Ab° mice on day 36 post-immunization for EAE. Inflammatory cell infiltration was visualized by H&E (A, D); demyelination by Luxol fast blue [(B) and enlarged inset, (E)]; axon damage by Bielschowsky’s silver staining [(C) and enlarged inset, (F)]. Vehicle-treated mice show large confluent inflammatory, demyelinating lesions with axon damage typical of MOG-EAE (arrowheads). OM-MOG-vaccinated mice showed no spinal cord pathology. Scale bars 500 μM (A–F), 100 μM enlarged inserts in middle panels. Representative sections from 1 of 4 (OM-MOG) or 5 (vehicle) mice per group are shown.