Figure 8.

Human myelin peptides induce proliferation responses of human peripheral blood mononuclear cells (PBMC). T cell responses to myelin peptide epitopes in peripheral blood monocytes (PBMC) from patients with relapsing-remitting multiple sclerosis (RRMS) and healthy individuals (see Table 2 ). Proliferation responses were measured by thymidine incorporation (CPM) in 48 replica wells/peptide/patient. The dotted lines represent the threshold set for the mean + 3 SD of all the unstimulated wells (US), above which wells are considered positive. Peptide-specific responses were considered positive with two or more positive replicas.