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. 2020 Nov 19;11:584364. doi: 10.3389/fimmu.2020.584364

Figure 1.

Figure 1

NLRP3 Germline Mutant Protein Maps. (A) Schematic representation of NLRP3 mutation proteomic locations known to cause or be associated with cyropyrin-associated periodic syndromes (CAPS) inflammasomopathies [familial cold autoinflammatory syndrome (FCAS), Muckle-Wells Syndrome (MWS), and chronic infantile neurologic cutaneous and articular syndrome, also known as neonatal-onset multisystem inflammatory disease (CINCA/NOMID)], and other NLRP3-AID. Annotated at each mutated position is the specific amino acid substitution with notation for the diseases associated with the respective substitution corresponding with the color-coded legend in the top-right corner of the panel. Representative proteomic locations of NLRP3 mutations reported in (B) FCAS, (C) MWS, and (D) CINCA/NOMID. (E) The proportion of reported mutations for NLRP3-AID and other NLRP3-mutant conditions color-coded in the legend below the graph. NAIP CIITA HET-E TEP1 (NACHT) domain inset annotations: WA, Walker A motif; WB, Walker B motif; S1, Sensor 1 motif; S2, Sensor 2 motif; GxP, GxP motif.