Figure 3.

Structurally Disruptive Mutation Sites. Representative locations of (A) severely-disruptive mutations (p_w < 0.01; boxes highlight NAIP CIITA HET-E TEP1 (NACHT) domain [solid line] and ATP binding site [dashed line]; inset shows enlarged ATP binding site with labeled mutation sites), (B) moderately-disruptive mutations (0.01 < p_w < 0.05), and (C) mildly-disruptive mutations (p_w > 0.05) mapped on our NLRP3 homology model, which excludes mutations in the PYR domain and beyond Leu943. (D) All germline mutations in PYR mapped on the NLRP3 PYR crystal structure. Severely-disruptive mutations in deep blue, moderately-disruptive mutations in pale blue, mildly-disruptive mutations in cyan spheres.