Table 2.
Ranked Combinatorial Scores for NLRP3 Mutants with pw <0.05.
| Site | Mutation | pweighted |
|---|---|---|
| 262 | R262W | 0.002797268 |
| 527 | E527V | 0.003230007 |
| 261 | C261W | 0.003752929 |
| 416 | W416L | 0.004708504 |
| 305 | D305A | 0.006500263 |
| 262 | R262L | 0.007021087 |
| 262 | R262P | 0.007961164 |
| 757 | G757R | 0.009421334 |
| 525 | F525C | 0.009929316 |
| 527 | E527K | 0.010085693 |
| 679 | L679P | 0.010277819 |
| 307 | L307P | 0.010382365 |
| 305 | D305G | 0.012488896 |
| 438 | T438I | 0.012587706 |
| 443 | Y443H | 0.012587706 |
| 438 | T438P | 0.013202097 |
| 954 | T954M | 0.01688818 |
| 634 | L634F | 0.019636212 |
| 305 | D305H | 0.021691606 |
| 21 | D21H | 0.023883493 |
| 305 | D305N | 0.025728784 |
| 303 | G303D | 0.033630895 |
| 306 | E306K | 0.035895245 |
| 334 | S334N | 0.036482638 |
| 408 | M408T | 0.03648867 |
| 661 | M661K | 0.039405753 |
| 262 | R262Q | 0.041757421 |
| 31 | D31V | 0.042837947 |
| 581 | F581Y | 0.043414953 |