Table 1.
Sequence of the oligomers used for the study and their propensity to fold into G-quadruplex or i-motif structures
| Oligomer | Sequence (5′→ 3′) | Structure formation | G4 orientation | BG4 binding |
|---|---|---|---|---|
| RT17 | GCGCGGGGAGGGGAGAGGGGGCGGGAGCGGC | G4 | PARALLEL | ++++ |
| MN89 | GCCGCTCCCGCCCCCTCTCCCCTCCCCGCGC | i-motif | — | — |
| BTM6 | GAAGGACCACAGGATATCTCTATATAAATCTGT | NA | — | — |
| KD53 | GCTCCGCCCCGCGCCCCCGGAAACCTCC | i-motif | — | — |
| KD52 | GGAGGTTTCCGGGGGCGCGGGGCGGAGC | G4 | PARALLEL | +++ |
| SMJ36 | GTCCCAATTCCCATATTGAAATCCCCAATCCCAA | NA | — | — |
| SMJ37 | CAGGGTTAAGGGTATAACTTTAGGGGTTAGGGTT | G4 | HYBRID | — |
| KD16 | ACTGGGGCTGGGGTGGGGGGTAATCCAGAACTGGATCGGGGT | G4 | PARALLEL | ++ |
| KD17 | ACCCCGATCCAGTTCTGGATTACCCCCCACCCCAGCCCCAGT | NO | — | — |
| DG1 | GATCCCTCTAGACCGGTACTACTCGAGCTTGGTTGCAGATTAAGAGAGGCTCCTG | NA | — | — |
| KD50 | CTCCGCCCCGCCGGGACCCCGCCCCCGGCCCG | i-motif | — | |
| KD49 | CGGGCCGGGGGCGGGGTCCCGGCGGGGCGGAG | G4 | PARALLEL | ++ |
| KD80 | GCCCCGGCCCCTAGCGCGCGACTCCT | i-motif | — | |
| KD81 | AGGAGTCGCGCGCTAGGGGCCGGGGC | G4 | PARALLEL | +++ |
| KD83 | AGGCCGGAGGGTGGGCGGCGCGCGG | G4 | PARALLEL | + |
| SV23 | GGGTTAGGGTTAGGGTTAGGG | G4 | ANTIPARALLEL | — |
| SV24 | CCCTAACCCTAACCCTAACCC | i-motif | — | — |
| SV25 | GGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG | G4 | ANTIPARALLEL | — |
| SV26 | CCCTAACCCTAACCCTAACCCTAACCCTAACCC | i-motif | — | — |
| SV27 | GGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGGTTAGGG | G4 | ANTIPARALLEL | — |
| SV28 | CCCTAACCCTAACCCTAACCCTAACCCTAACCCTAACCCTAACCC | i-motif | — | — |
| SMJ50 | TCGGGTTGCGGGCGCAGGGCACGGGCG | G4 | PARALLEL | — |
| SMJ51 | GTGGGGTTAGGGGTTAGGGGTTAGGGG | G4 | HYBRID | — |
| SMJ52 | TTGGGGCCGGGGCCGGGGCCGGGGTT | G4 | HYBRID | — |
| SMJ53 | GTAGGGTTAGGGTTAGGGTTAGGG | G4 | HYBRID | — |
| SMJ56 | TGGGTTTGGGTTTGGGTTTGGGT | G4 | HYBRID | — |
| SMJ58 | GGGGAGTAAAAGGGAGCGGGGTGCTGGG | G4 | HYBRID | — |
| SMJ59 | GGGCCTTGTGGGCCTTGTGGGCCTTGTGGG | G4 | ANTIPARALLEL | — |
| SMJ61 | GGGGTTTTGGGGTTTTGGGGTTTTGGGG | G4 | HYBRID | — |
| AKN11 | GACCTGAGGGCGAGCTTTTTTCGAGTAACTTAACAG | NA | — | — |
| AKN18 | CTGTTAAGTTACTCGAAAAAAGCTCGCCCTCAGGTC | NA | — | — |