Fig. 9.

A: Average stability changes, as predicted by mCSM and depicted on the model. Regions in red indicate average destabilizing effects for all possible mutations at a specific residue position and blue indicate stabilizing effect. B. The average impact score mapped on the structure. C: Average of mCSM stability predictions for all possible mutations within the Ofloxacin binding site. Red color indicates that on an average, any mutation in this site induces a destabilizing effect on the protein. (For interpretation of the references to color in this figure legend, the reader is referred to the web version of this article.)