Table 5.
Mutations in GYR | mCSM (ΔΔG in kcal/mol) | Prime MM/GBSA (ΔΔG in kcal/mol) | mCSM-NA (ΔΔG in kcal/mol) | mCSM-PPI (ΔΔG in kcal/mol) | DynaMut (ΔΔG in kcal/mol) | Overall Impact | Reference |
---|---|---|---|---|---|---|---|
A91T | −0.70 | −8.54 | 1.48 | −0.28 | −0.66 | High Impact | [54] |
A91V | −0.32 | 5.43 | 0.44 | −0.59 | −0.27 | High Impact | [50] |
S92A | −0.60 | −12.35 | −1.09 | 0.20 | 1.55 | High Impact | [54] |
R107L | −0.50 | −6.33 | −1.53 | 0.12 | −0.26 | Moderate Impact | [49] |