Table 1.

Roles of Bikunin, HCs, and the IαI Family.

IαI Family	Bikunin	HCs
■ Stabilizes HA via crosslinking with HCs ■ Controls neutrophil activation ■ Plasmin inhibitor ■ Inhibits complement ■ Inhibits hyaluronidase	■ Serine protease inhibitor ■ Inhibits cell migration/invasion ■ Decreases cell proliferation ■ Disrupts growth factor signaling ■ Inhibits cytokine release ■ Inhibits calcium channel–dependent signaling ■ Inhibits calcium oxalate crystallization	■ Bind extracellular matrix components such as vitronectin ■ Inhibit complement

Abbreviations: HA, hyaluronan; HCs, heavy chains; IαI, inter-α-trypsin inhibitor.