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. 2020 Dec 3;26:120. doi: 10.1186/s10020-020-00248-1

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Histological images in bone tissues in both groups detected via H&E staining (× 400). No obvious osteonecrosis was observed in control group (a). Typical osteonecrosis of the femoral heads was observed in model group (b–d). Scale bar = 100 um. The rate of empty lacunae in model group was significantly higher than that control group at each time point (e) (*compared with control group, P < 0.05. The red arrow shows the empty lacunae, and the black arrow shows the fat cells). Model group vs control group: the 2nd week (n = 9 vs 8), 4th week (n = 8 vs 8), and 6th week (n = 9 vs 8)