Fig. 2.

Family pedigree of patient #13, harboring a heterozygous novel splice site variant (c.1608+2T>C) in the LMNA gene. The proband is indicated by an arrowhead (III-2) and subjects possibly affected by laminopathy are colored in grey. Subjects II-5, III-1 and III-2 suffered from second degree atrioventricular block and dilated cardiomyopathy and underwent either a permanent pacemaker or an implantable cardioverter-defibrillator insertion. The symbol for deceased subjects is marked with a diagonal bar and age of death is placed in the upper right corner.