Table 1.

miRNAs related to OSA, target of these miRNAs, result of aberrant expression and possible uses.

miRNAs	Expression Profiles in OSA	Target Genes or Proteins	Result of Aberrant miRNA Expression	Possible Uses
miR-1 and miR-133b	Reduced expression	MET and MCL1	Cell proliferation and growth Cancer cells Invasion Cancer cells Survival Inhibition of apoptosis	Diagnostic biomarker for canine OSA
miR-9	Overexpression	Gelsolin	Cell motility and invasive capacity increase Promotion of metastasis	Possible prognostic biomarker
miR-196a	Reduced expression	Annexin 1	Facilitates migration and invasion Cancer cells adhesion and migration Mediates VEGF1 induced cell migration	Potential prognostic biomarker
14q32 locus (miR-544, miR-369-3p, miR-134 and miR-382)	Reduced levels	cMYC	Promotion of metastasis Poorer survival rates Inhibition of apoptosis Tumorigenesis maintenance	Potential prognostic biomarker Potential therapeutic target
miR-34a	Reduced levels	MET, SIRT1, CDK6, VEGF1	Mediates VEGF1 induced cell migration Shorter disease-free survival times	Potential prognostic biomarker Potential therapeutic target
miR-106b-25 cluster (miR-106b, miR-25 and miR-93-5p)	Overexpression	p21	Cell proliferation and growth Cancer cells Invasion Cell cycle promotors Activation of tumorigenesis	Potential prognostic biomarker
Circulating miR-214	Increased levels in circulation		Shorter survival times	Potential non-invasive predictive biomarker
Circulating miR-126	Increased levels in circulation		Longer survival times	Potential non-invasive predictive biomarker