Table 2.
Demographics, underlying diseases, radiographic findings, and test results for 20 patients who underwent bronchoscopy and bronchoalveolar lavage and who were diagnosed with invasive pulmonary aspergillosis.
| Age/Gender/ Comorbidity |
Aspergillosis Category | GM BALF (ODI) |
GM Serum (ODI) |
Asp GM-LFA BALF (Visual Reading) |
Asp GM-LFA BALF (Digital Reader) |
BALF Culture | CT Chest Findings | ||
|---|---|---|---|---|---|---|---|---|---|
| Test 1 | Test 2 | Test 1 | Test 2 | ||||||
| 70/F/Lung Tx | Proven at autopsy | NA | NA | + | + | 1.41 | 1.63 | A. fumigatus | Cavitary nodule, ggo, consolidation |
| 42/M/ Cushing’s D., critical illness |
Proven at autopsy | <0.5 | <0.5 | NEG | NEG | 0.00 | 0.045 | No growth | Pulmonary nodules, ggo |
| 19/F/CPD | Proven at lobectomy | 3.2 | NA | + | + | 2.13 | 2.63 | A. fumigatus | Cavitary nodules, consolidation |
| 67/M/Lung Tx | Probable | 6.7 | <0.5 | NEG | NEG | 0.43 | 0.34 | A. fumigatus | Pulmonary nodules |
| 22/M/AML | Probable | 6.2 | <0.5 | NEG | NEG | 0.06 | 0.01 | No growth | Pulmonary nodules |
| 42/M/Lung Tx | Probable | <0.5 | NA | NEG | NEG | 0.25 | 0.26 | A. fumigatus | Pulmonary nodules |
| 62/M/Lung Tx | Probable | <0.5 | NA | NEG | NEG | 0.00 | 0.06 | A. fumigatus | Diffuse pulmonary infiltrates, ggo |
| 23/F/Lung Tx | Probable | <0.5 | <0.5 | NEG | NEG | 0.23 | 0.10 | A. fumigatus | Pulmonary nodules |
| 66/M/CMML | Probable | <0.5 | 1.75 | NEG | NEG | 0.00 | 0.09 | No growth | Pulmonary nodules, ggo |
| 79/F/CLL | Probable | NA | <0.5 | NEG | NEG | 0.13 | 0.23 | A. fumigatus | Pulmonary nodules |
| 58/F/ Steroids 1, critical illness |
Probable | 7.6 | NA | ++ | + | 3.16 | 2.88 | NA | Pulmonary nodules |
| 57/M/ HIV, CD4 < 200 |
Probable | 7.4 | <0.5 | NEG | NEG | 0.45 | 0.09 | No growth | Consolidation, pulmonary nodules |
| 49/F/Lung Tx | Probable 2 | NA | NA | NEG | NEG | 0.18 | 0.00 | A. fumigatus | No pulmonary changes |
| 68/M/MDS | Probable | 2.43 | <0.5 | + | + | 1.20 | 1.51 | No growth | Cavitary nodules, ggo, consolidation |
| 54/F/Steroids | Probable | 8.14 | <0.5 | ++ | ++ | 5.24 | 6.29 | A. fumigatus | Cavitary nodule, ggo |
| 63/M/Lung Tx 3 | Probable | NA | <0.5 | NEG | NEG | 0.00 | 0.06 | A. fumigatus | Pulmonary nodules |
| 59/M/ Lung Tx, MDS |
Probable | NA | NA | +++ | +++ | 19.32 | 18.83 | A. fumigatus | Pulmonary nodules |
| 76/M/Steroids 1 | Probable | NA | NA | ++ | ++ | 5.97 | 6.73 | A. fumigatus | Dense lesion with halo sign, consolidation |
| 65/M/Lung Tx | Probable 2 | NA | NA | +++ | +++ | 19.9 | 19.43 | A. terreus | Soft tissue density at anastomosis |
| 60/F/CPD | Probable | NA | NA | NEG | NEG | 0.34 | 0.37 | A. fumigatus | Pulmonary nodules, ggo |
1 Dose equivalent to ≥0.3 mg/kg prednisone daily for ≥3 weeks at the time of bronchoscopy; 2 tracheobronchial anastomotic infection; 3 patient on isavuconazole for prophylaxis within 5 days prior to bronchoscopy. +, ++, +++ refer to the strength of the positive test