Table 2.
Metabolites that were affected by radiotherapy. Listed are compounds where differences between paired pre-RT (samples A) and post-RT (samples C) specimens showed a large effect size (Cohen’s d effect size ≥ 0.8).
| Metabolite Name | Class | Mean Abundance Pre-RT (Samples A) |
Mean Abundance Post-RT (Samples B) |
Significance of Differences between Pre-RT and Post-RT (Cohen’s D Effect Size) |
|---|---|---|---|---|
| Serum Metabolites | ||||
| Upregulated by RT | ||||
| Hypotaurine | Others | 6.48 × 10−5 | 1.09 × 10−4 | −1.16 |
| Glycerol-1-phosphate | Glycerolipids | 1.03 × 10−4 | 1.46 × 10−4 | −1.06 |
| Oleamide | Fatty acids | 6.71 × 10−5 | 1.77 × 10−4 | −0.81 |
| Serotonin | Amines | 5.43 × 10−5 | 6.71 × 10−5 | −0.81 |
| Downregulated by RT | ||||
| 1-Methylhistidine | Amino acids | 1.13 × 10−4 | 7.84 × 10−5 | 0.96 |
| Urea | Others | 1.81 × 10−4 | 4.76 × 10−2 | 0.96 |
| Quinic acid | Others | 7.48 × 10−5 | 5.60 × 10−5 | 0.87 |
| 2-ketoglucose dimethylacetal | Hydroxy acids | 1.68 × 10−4 | 7.86 × 10−5 | 0.85 |
| 4-Deoxyerythronic acid | Sugar acids | 4.44 × 10−5 | 2.77 × 10−5 | 0.85 |
| Galactosylglycerol | Glycerolipids | 4.55 × 10−5 | 1.69 × 10−5 | 0.85 |
| Gentisic acid | Carboxylic acids | 6.36 × 10−6 | 3.78 × 10−6 | 0.85 |
| D-Xylitol | Sugar alcohols | 2.29 × 10−4 | 1.49 × 10−4 | 0.82 |