Table 5.

Comparisons of NTCP calculations for TG‐166 test cases between TPS results and those obtained from Mobius3D and COMPASS, using the two described models (Lyman‐Kutcher‐Burman and Niemierko)

	NTCP LKB				NTCP Niemierko
		Differences (%)			Differences (%)
	TPS Values	M3D	CC	CR	TPS values	M3D	CC	CR
Benchmark Phantom
PTV R	19.5	$-3.2$	$-1.1$	$-0.3$	22.4	$-2.7$	$-0.4$	$-0.2$
Rect1	3.1	0.2	$-0.1$	$-0.2$	3.4	0.4	$-0.9$	$-1.0$
Rect2	21.6	$-1.0$	2.9	3.1	22.6	$-1.0$	2.8	3.0
Triang1	29.3	4.1	5.0	5.3	30.1	2.9	3.7	3.8
Head & Neck
Cord	$38.7\cdot {10}^{-2}$	$-3.2\cdot {10}^{-2}$	$-2.4\cdot {10}^{-2}$	$-4.3\cdot {10}^{-2}$	$14.6\cdot {10}^{-2}$	$-1.4\cdot {10}^{-2}$	$-1.0\cdot {10}^{-2}$	$-1.9\cdot {10}^{-2}$
L Parot	$38.0\cdot {10}^{-2}$	$8.1\cdot {10}^{-2}$	$9.7\cdot {10}^{-2}$	$-8.9\cdot {10}^{-2}$	$7.9\cdot {10}^{-2}$	$0.5\cdot {10}^{-2}$	$2.8\cdot {10}^{-2}$	$-2.0\cdot {10}^{-2}$
R Parot	$38.3\cdot {10}^{-2}$	$-4.0\cdot {10}^{-2}$	$3.1\cdot {10}^{-2}$	$-8.6\cdot {10}^{-2}$	$6.3\cdot {10}^{-2}$	$-2.2\cdot {10}^{-2}$	$0.8\cdot {10}^{-2}$	$-3.6\cdot {10}^{-2}$
Mandbl	$3.2\cdot {10}^{-2}$	$2.5\cdot {10}^{-2}$	$1.3\cdot {10}^{-2}$	$0.5\cdot {10}^{-2}$	$32.0\cdot {10}^{-2}$	$18\cdot {10}^{-2}$	$8.2\cdot {10}^{-2}$	$2.1\cdot {10}^{-2}$
	Prostate
Rectum	$11.1\cdot {10}^{-2}$	$4.2\cdot {10}^{-2}$	$1.1\cdot {10}^{-2}$	$4.4\cdot {10}^{-2}$	$4.4\cdot {10}^{-3}$	$2.1\cdot {10}^{-3}$	$0.6\cdot {10}^{-3}$	$2.2\cdot {10}^{-3}$
Bladder	$3.1\cdot {10}^{-12}$	$1.2\cdot {10}^{-12}$	$0.2\cdot {10}^{-12}$	$3.7\cdot {10}^{-12}$	$5.0\cdot {10}^{-3}$	$-1.2\cdot {10}^{-3}$	$-0.2\cdot {10}^{-3}$	$-2.6\cdot {10}^{-3}$
L FemH	$24.5\cdot {10}^{-11}$	$-5.2\cdot {10}^{-11}$	$6.6\cdot {10}^{-11}$	$0.9\cdot {10}^{-11}$	$18.6\cdot {10}^{-10}$	$0.2\cdot {10}^{-10}$	$8.1\cdot {10}^{-10}$	$2.8\cdot {10}^{-10}$
R FemH	$4.0\cdot {10}^{-10}$	$-1.2\cdot {10}^{-10}$	$0.8\cdot {10}^{-10}$	$0.1\cdot {10}^{-10}$	$26.9\cdot {10}^{-10}$	$-2.3\cdot {10}^{-10}$	$8.5\cdot {10}^{-10}$	$6.4\cdot {10}^{-10}$
PBone	$3.4\cdot {10}^{-3}$	$0.8\cdot {10}^{-3}$	$1.6\cdot {10}^{-3}$	$-1.2\cdot {10}^{-3}$	$3.5\cdot {10}^{-2}$	$1.3\cdot {10}^{-2}$	$1.5\cdot {10}^{-2}$	$-1.3\cdot {10}^{-2}$
	Brain
BStem	$14.8\cdot {10}^{-2}$	$1.2\cdot {10}^{-2}$	$-2.2\cdot {10}^{-2}$	$1.9\cdot {10}^{-2}$	$4.6\cdot {10}^{-2}$	$1.5\cdot {10}^{-2}$	$-4.7\cdot {10}^{-2}$	$5.6\cdot {10}^{-2}$
OptCh	$10.3\cdot {10}^{-1}$	$-1.1\cdot {10}^{-1}$	$-0.3\cdot {10}^{-1}$	$-4.9\cdot {10}^{-1}$	$17.6\cdot {10}^{-1}$	$-1.7\cdot {10}^{-1}$	$0.0\cdot {10}^{-1}$	$-6.1\cdot {10}^{-1}$
L Eye	$25.7\cdot {10}^{-5}$	$-2.7\cdot {10}^{-5}$	$0.6\cdot {10}^{-5}$	$-10\cdot {10}^{-5}$	$6.8\cdot {10}^{-5}$	$0.0\cdot {10}^{-5}$	$0.8\cdot {10}^{-5}$	$-6.1\cdot {10}^{-5}$
R Eye	$36.0\cdot {10}^{-5}$	$-3.0\cdot {10}^{-5}$	$1.0\cdot {10}^{-5}$	$-5.6\cdot {10}^{-5}$	$7.2\cdot {10}^{-5}$	$-0.5\cdot {10}^{-5}$	$0.9\cdot {10}^{-5}$	$-1.7\cdot {10}^{-5}$
L OptN	$2.8\cdot {10}^{-4}$	$2.0\cdot {10}^{-4}$	$0.8\cdot {10}^{-4}$	$-5.7\cdot {10}^{-4}$	$7.7\cdot {10}^{-3}$	$4.4\cdot {10}^{-3}$	$1.3\cdot {10}^{-3}$	$-14\cdot {10}^{-3}$
R OptN	$1.2\cdot {10}^{-3}$	$0.2\cdot {10}^{-3}$	$0.3\cdot {10}^{-3}$	$-2.6\cdot {10}^{-3}$	$3.9\cdot {10}^{-2}$	$1.2\cdot {10}^{-2}$	$1.1\cdot {10}^{-2}$	$-4.3\cdot {10}^{-2}$
L InnE	$1.8\cdot {10}^{-2}$	$1.5\cdot {10}^{-2}$	$1.1\cdot {10}^{-2}$	$1.3\cdot {10}^{-2}$	$13.8\cdot {10}^{-1}$	$6.1\cdot {10}^{-1}$	$2.7\cdot {10}^{-1}$	$4.2\cdot {10}^{-1}$
R InnE	$8.6\cdot {10}^{-1}$	$6.4\cdot {10}^{-1}$	$3.9\cdot {10}^{-1}$	$5.5\cdot {10}^{-1}$	5.8	2.6	1.3	1.7
			M3D vs. CC		M3D vs. CR		CC vs. CR
		p‐values	0.11		0.12		0.50

$\mathrm{M}3\mathrm{D}=\text{Mobius}3\mathrm{D}$; $\text{CC}=\text{COMPASS dose calculation}$; $\text{CR}=\text{COMPASS dose reconstruction}$; $\text{PTV R}=\text{PTV Rectangle}$; $\text{Rect}=\text{Rectangle}$; $\text{Triangl}=\text{Triangle}\hspace{0.17em}1$; $\text{Parot}=\text{parotid glands}$; $\text{Mandbl}=\text{mandible}$; $\text{FemH}=\text{femoral heads}$; $\text{Pbone}=\text{pubic bone}$; $\text{Bstem}=\text{brain stem}$; $\text{OptCh}=\text{optic chiasm}$; $\text{OptN}=\text{optic nerve}$; $\text{InnE}=\text{inner ear}$.