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. 2020 Nov 19;10(4):236. doi: 10.3390/jpm10040236

Figure 1.

Figure 1

DUX4 binding sites at loci surrounding miRNAs dysregulated in FSHD patients. The 19 miRNAs dysregulated in FSHD1 patient plasma samples were queried for potential regulation by the DUX4 transcription factor, which aberrantly expressed in FSHD, using a DUX4 ChIP-seq dataset [9]. (a) Overview of all DUX4 binding sites within regions capable of acting as regulatory elements (100 kb) of the 19 miRNAs and their home genes. (b) Schematic of DUX4 binding sites within the miR-100 locus and its surrounding home gene (MIR100HG) variants. Note, miR-100 is transcribed from right to left on this image. Corresponding epigenetic modification maps display the location of histone modifications associated with active promoters (H3K4me3) and poised/active enhancers (H3K4me1 and H3K27Ac, respectively).