Figure 3.

Pathway analysis of miRNAs and transcription factors dysregulated by FSHD mutations. Ingenuity Pathway Analysis software was used to identify established connections between candidate miRNAs from this study with transcription factors known to be dysregulated by FSHD-causing overexpression of DUX4 [9]. Red-shaded miRNAs and transcription factors were observed to increase, while those shaded blue were observed to decrease. Solid arrows denote direct relationships, while dashed arrows denote indirect relationships.