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. 2020 Oct 9;8(4):25. doi: 10.3390/jdb8040025

Figure 1.

Figure 1

Individuals affected by EVC, LIMBIN mutant cattle, and Evc2/Limbin mutant mice share similar dwarfism. (A) A 20-month-old infant affected by EVC syndrome (left) and a 20-month-old infant without EVC syndrome (right) © BMJ. The infant with EVC syndrome has un-proportional shortened legs. (B) A LIMBIN mutant cattle bears apparent short legs. (C) Evc2/Limbin mutant mice with littermate controls exhibit a smaller body size at 5 weeks old. (D) LIMBIN mutant cattle have decreased size of growth plate (marked in white arrow) in appendicular bones. (E) The growth plate of tibia from Evc2/Limbin mutant mice demonstrate shorter and disorganized structure at 5 weeks old compared with control mice. Bars indicate 200 um. (F) Tibiae from E18.5 mouse embryos were stained with alcian blue for cartilage and alizarin red for bone. Tibiae from Evc2/Limbin mutant embryos are shorter than those in control littermates, although body size in these two groups are similar at this stage.