Table 1. Baseline Characteristics of the Ustekinumab and Secukinumab Cohorts.
| Characteristic | No. (%) | |
|---|---|---|
| Ustekinumab cohort (n = 917) | Secukinumab cohort (n = 314) | |
| Age, median (IQR), y | 45.0 (35.0-55.0) | 46.0 (36.0-55.0) |
| Female sex | 365 (39.8) | 121 (38.5) |
| BMI | 30.9 (26.6-36.5) | 30.5 (26.7-35.1) |
| Weight, median (IQR), kg | 92.0 (77.2-107.5) | 89.4 (76.4-107.0) |
| Alcohol | ||
| No documented alcohol intake | 338 (36.9) | 115 (36.6) |
| Lower-risk drinking (male: <21 U/wk; female: <14 U/wk) | 470 (51.3) | 160 (51.0) |
| Hazardous drinking (male: <50 U/wk; female: <35 U/wk) | 96 (10.5) | 36 (11.5) |
| Harmful drinking (male: ≥50 U/wk; female: ≥35 U/wk) | 13 (1.4) | 3 (1.0) |
| Smoking status | ||
| Never | 320 (34.9) | 126 (40.1) |
| Previous | 346 (37.7) | 109 (34.7) |
| Current | 251 (27.4) | 79 (25.2) |
| Baseline PASI | 16.3 (13.9-21.1) | 17.6 (14.4-22.7) |
| Psoriatic arthritis | 135 (14.7) | 64 (20.4) |
| No. of previous biologic therapies | ||
| None | 770 (84.0) | 261 (83.1) |
| 1 | 103 (11.2) | 33 (10.5) |
| 2 | 33 (3.6) | 16 (5.1) |
| ≥3 | 11 (1.2) | 4 (1.3) |
| No. of previous conventional therapies | ||
| None | 72 (7.9) | 30 (9.6) |
| 1 | 209 (22.8) | 88 (28.0) |
| 2 | 302 (32.9) | 120 (38.2) |
| ≥3 | 334 (36.4) | 76 (24.2) |
| Previously treated with TNF inhibitors | 144 (15.7) | 50 (15.9) |
| Treated with a concomitant systemic therapy | 118 (12.9) | 15 (4.8) |
| No. of comorbid conditions | ||
| None | 262 (28.6) | 108 (34.4) |
| 1-2 | 463 (50.5) | 152 (48.4) |
| 3-4 | 152 (16.6) | 45 (14.3) |
| ≥5 | 40 (4.4) | 9 (2.9) |
| Psoriasis | ||
| Palmoplantar | 189 (20.6) | 58 (18.5) |
| Nail | 488 (53.2) | 174 (55.4) |
| Scalp | 690 (75.2) | 234 (74.5) |
| Depression | 227 (24.8) | 62 (19.7) |
| Working status | ||
| Full-time | 493 (53.8) | 191 (60.8) |
| Part-time | 111 (12.1) | 35 (11.1) |
| Full-time in the home | 30 (3.3) | 13 (4.1) |
| Unemployed but seeking work | 39 (4.3) | 11 (3.5) |
| Not working because of disability/ill health | 117 (12.8) | 28 (8.9) |
| Student | 22 (2.4) | 6 (1.9) |
| Retired | 105 (11.5) | 30 (9.6) |
| Race/ethnicity | ||
| White | 816 (89.0) | 289 (92.0) |
| Black | 9 (1.0) | 0 |
| Asian | 54 (5.9) | 14 (4.5) |
| Other | 38 (4.1) | 11 (3.5) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); IQR, interquartile range; PASI, Psoriasis Area and Severity Index; TNF, tumor necrosis factor.