Table 2.

Approved antifungals for clinical usage.

Antifungal Class	Fungal Targets	Mechanism of Action	Limitation	References
Azoles	Aspergillus, Candida, Cryptococcus	Interference with ergosterol biosynthesis via 14α-demethylase inhibition	Fungistatic	[4,5]
Polyenes	Aspergillus, Candida, Cryptococcus, Histoplasma, Blastomyces	Ergosterol extraction from plasma membrane	Toxicity	[4]
Echinocandins	Aspergillus, Candida	β-1,3-glucan synthase inhibition	Poor oral bioavailability	[7]