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. 2020 Oct 29;8(4):94. doi: 10.3390/toxics8040094

Table 1.

Alteration in ovaries induced by cadmium.

Administration/Dose/Species/Form Changes References
Per os
  • -

    Higher number of antral and atretic follicles

 Ruslee et al., 2020 [39]
5 mg/kg; 6 weeks, daily; 6 weeks
Sprague Dawley rats
CdCl2
Single i.p.
  • -

    Decrease in the relative volume of growing follicles;

  • -

    Increased number of atretic follicles

 Massanyi et al., 2020 [37]
1.5 mg/kg; killed after 48 h
Per os
1.0 mg/kg/day; 5 months
Rabbits
CdCl2
Per os (gavage)
  • -

    Prolongation of the cycle length

  • -

    Degeneration of the corpus luteum

  • -

    Damaged and fewer oocytes

 Nasiadek et al., 2019 [40]
0.09–4.5 mg/kg, 90 days
Rat (Wistar)
CdCl2
Per os
  • -

    Decrease in follicle number

 Nna et al., 2017 [41]
5 mg/kg; 14 day
Rat (Wistar)
CdCl2
Per os
  • -

    Increased numbers of atretic follicles

  • -

    Decreased number of follicles in different stages of maturation

  • -

    Disorganization, edema and decreased number of yellow bodies

 Lubo-Palma et al., 2006 [52]
50, 100 and 150 ppm (in water); 50 days
Swiss albino mice
CdCl2

i.p.—intraperitoneal administration.