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. 2020 Dec 3;21(6):409–419. doi: 10.1038/s41435-020-00120-6

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© The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic of SARS-CoV-2 genome. Genomic organization of SARS-CoV-2 with numbering above the block referring to nucleotide positions. Structural proteins, including spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins, as well as nonstructural proteins (nsps) translated from ORF1ab and accessory proteins are indicated. b Schematic of 7096-aa replicase polyprotein pp1ab with its 15 sub-proteins (nsp1–nsp10 and nsp12–nsp16). c Comparative sequence analysis of the pp1ab domain for completely sequenced genomes of SARS-CoV-2 from at least 39 distinct global territories. SARS-CoV-2 sequences were compared to the corresponding homologous sequence from batSL-CoVs and SARS-CoVBJ01. Macrodomains within Nsp3 are demarcated by red arrow. Y axis depicts similarity scores between CoVs and the X axis refers to the relative residue position. Lower scores signify low sequence conservation, with trough corresponding to the least conserved regions. d Macrodomains sequences encoding Mac-1, Mac-2, and Mac-3 proteins exhibiting exceptional divergence in SARS-CoV-2 relative to bat-RaTG13/ZC45/ZXC21 and SARS-CoVBJ01. Green, red, and blue circles, respectively, differentiate between Mac-1, Mac-2, and Mac-2 specific substitutions.