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Pedigree chart showing autosomal dominant inheritance in the families; circle denotes females, square males. The proband is indicated by arrow mark in each family, dotted symbol denote person with diabetes with unknown mutation status and solid symbols denote affected subjects with (Family 1) INSR gene p.(Met1180Lys) or (Family 2) INSR gene p.(Arg1119Gln) or (Family 3) INSR gene c.3572G>A, p.(Arg1191Gln) mutation
