Table 3.
Mean ±SD for 2D transthoracic echocardiographic parameters at baseline and at 6 months and 3 years follow-up.
| Basal | 6 Months | 3 Years | p-Value | |
|---|---|---|---|---|
| All Patients (295 patients) | ||||
| Mitral regurgitation grade | 3.9 ± 0.2 | 0.6 ± 0.7 * | 0.9 ± 0.9 †,* | <0.001 |
| Left ventricular end diastolic volume index (mL/m2) | 77.4 ± 19.3 | 57.3 ± 14.9 * | 56.9 ± 17.8 * | <0.001 |
| Left ventricular end systolic volume index (mL/m2) | 27.0 ± 9.6 | 24.6 ± 10.7 * | 23.9 ± 12.3 * | <0.001 |
| Left ventricular stroke volume index (mL/mq) | 50.4 ± 12.8 | 32.6 ± 7.5 * | 32.9 ± 8.3 * | <0.001 |
| Left ventricular ejection fraction (%) | 65.2 ± 6.8 | 57.9 ± 8.0 * | 59.2 ± 7.7 †,* | <0.001 |
| Left atrial volume index (mL/m2) | 66.4 ± 24.8 | 45.4 ± 17.7 * | 44.5 ± 18.5 * | <0.001 |
| Tricuspid regurgitation grade | 1.0 ± 0.8 | 0.9 ± 0.4 | 1.0 ± 0.4 † | 0.024 |
| Pulmonary artery systolic pressure (mmHg) | 36.4 ± 11.1 | 28.1 ± 5.9 * | 29.5 ± 7.6 †,* | <0.001 |
| Group 1: 6M-MR < 2 (266 patients) | ||||
| Mitral regurgitation grade | 3.9 ± 0.2 | 0.4 ± 0.4 * | 0.7 ± 0.7 *,† | <0.001 |
| Left ventricular end diastolic volume index (mL/m2) | 77.0 ± 18.9 | 56.7 ± 14.6 * | 55.9 ± 17.0 * | <0.001 |
| Left ventricular end systolic volume index (mL/m2) | 26.8 ± 9.2 | 24.5 ± 10.7 * | 23.4 ± 11.9 * | <0.001 |
| Left ventricular stroke volume index (mL/m2) | 50.1 ± 12.7 | 32.2 ± 7.2 * | 32.5 ± 8.0 * | <0.001 |
| Left ventricular ejection fraction (%) | 65.2 ± 6.7 | 57.7 ± 7.8 * | 59.3 ± 7.6 †,* | <0.001 |
| Left atrial volume index (mL/m2) | 66.1 ± 24.4 | 44.5 ± 17.5 * | 43.1 ± 17.7 †,* | <0.001 |
| Tricuspid regurgitation grade | 1.0 ± 0.8 | 0.9 ± 0.3 | 1.0 ± 0.4 | 0.066 |
| Pulmonary artery systolic pressure (mmHg) | 35.4 ± 9.8 | 27.7 ± 5.6 * | 28.7 ± 6.8 * | <0.001 |
| Group 2: 6M-MR ≥2 (29 patients) | ||||
| Mitral regurgitation grade | 3.9 ± 0.3 | 2.1 ± 0.3 ‡,* | 2.7 ± 0.7 ‡,†,* | <0.001 |
| Left ventricular end diastolic volume index (mL/m2) | 82.2 ± 22.8 | 62.9 ± 16.0 ‡,* | 66.0 ± 22.0 ‡,* | <0.001 |
| Left ventricular end systolic volume index (mL/m2) | 29.4 ± 12.7 | 25.9 ± 10.7 | 28.8 ± 14.7 ‡ | 0.263 |
| Left ventricular stroke volume index (mL/m2) | 52.7 ± 13.6 | 37.0 ± 8.8 ‡,* | 37.1 ± 9.6 ‡,* | <0.001 |
| Left ventricular ejection fraction (%) | 65.1 ± 7.7 | 59.8 ± 9.6 * | 57.8 ± 8.2 * | <0.001 |
| Left atrial volume index (mL/m2) | 68.9 ± 28.1 | 53.6 ± 17.6 ‡,* | 56.6 ± 21.8 ‡,* | 0.002 |
| Tricuspid regurgitation grade | 1.3 ± 1.0 | 1.1 ± 0.7 | 1.3 ± 0.7 ‡ | 0.270 |
| Pulmonary artery systolic pressure (mmHg) | 45.2 ± 16.8 ‡ | 31.8 ± 7.4 ‡,* | 37.0 ± 10.1 ‡,†,* | <0.001 |
* p < 0.05: vs. baseline, † p < 0.05: vs. 6 months, ‡ p < 0.05: mitral regurgitation ≥2 vs. <2.