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. 2020 Oct 9;8(4):594. doi: 10.3390/vaccines8040594

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Lipid A structures of Escherichia coli and Bordetella pertussis (A) and those expected after replacing the acyltransferases in B. pertussis (B). The altered acyl chains that are introduced after replacing the acyltransferases of the wild type by the heterologous enzymes are shown in red. The heterologous enzymes expressed are indicated below the structures. Pa, Pseudomonas aeruginosa; Nm, Neisseria meningitidis; Pg, Porphyromonas gingivalis. 3OH-C14, 3OH-C12, and 3OH-C10 acyl chains are indicated as C14OH, C12OH, and C10OH, respectively.