Table 3.

Detected molecular alterations.

Genomic Alteration	Absolute Numbers	Frequency in %
TP53	228	19.9%	MET	9	0.8%	VA65:C90HL	4	0.3%	RHOA	2	0.2%
KRAS	103	9.0%	PTCH1	9	0.8%	CCND1	3	0.3%	ROS1	2	0.2%
PIK3CA	54	4.7%	RAD50	9	0.8%	CDH1	3	0.3%	SF3B1	2	0.2%
PTEN	37	3.2%	AKT1	8	0.7%	DDR2	3	0.3%	SRC	2	0.2%
APC	28	2.4%	FGFR3	8	0.7%	ESR1	3	0.3%	TERT	2	0.2%
CDKN2A	28	2.4%	SMARCB1	8	0.7%	FGFR4	3	0.3%	RHOA	2	0.2%
NOTCH1	26	2.3%	BRCA1	7	0.6%	HRAS	3	0.3%	ROS1	2	0.2%
ATM	25	2.2%	IDH2	7	0.6%	MAP2K1	3	0.3%	SF3B1	2	0.2%
SMAD4	19	1.7%	MSH6	7	0.6%	MYCL	3	0.3%	AKT2	1	0.1%
IDH1	17	1.5%	PALB2	7	0.6%	NTRK1	3	0.3%	AR	1	0.1%
PIK3R1	17	1.5%	SMARCA4	7	0.6%	PDGFRA	3	0.3%	AXL	1	0.1%
CTNNB1	16	1.4%	TSC1	7	0.6%	RAD51B	3	0.3%	CBL	1	0.1%
BRCA2	15	1.3%	ALK	6	0.5%	RNF43	3	0.3%	CD274	1	0.1%
RB1	15	1.3%	BAP1	6	0.5%	CDK4	2	0.2%	CDK4	1	0.1%
EGFR	14	1.2%	FGFR2	6	0.5%	CCND2	2	0.2%	CHEK2	1	0.1%
FANCA	14	1.2%	NBN	6	0.5%	CDK2	2	0.2%	FANCI	1	0.1%
POLE	14	1.2%	NF2	6	0.5%	CHEK1	2	0.2%	IGF1R	1	0.1%
TSC2	14	1.2%	SMO	6	0.5%	ERBB3	2	0.2%	JAK1	1	0.1%
ATR	13	1.1%	CDK12	5	0.4%	EZH2	2	0.2%	JAK2	1	0.1%
BRAF	13	1.1%	ERBB4	5	0.4%	FANCD2	2	0.2%	MAPK1	1	0.1%
NF1	13	1.1%	FGFR1	5	0.4%	FLT3	2	0.2%	MCL1	1	0.1%
ARID1A	12	1.0%	MLH1	5	0.4%	GNAQ	2	0.2%	MDM2	1	0.1%
CREBBP	12	1.0%	PMS2	5	0.4%	JAK3	2	0.2%	MDM4	1	0.1%
KIT	12	1.0%	PTPN11	5	0.4%	MAF	2	0.2%	MSH	1	0.1%
FBXW7	11	1.0%	ABL1	4	0.3%	MAX	2	0.2%	NFE2L2	1	0.1%
RET	11	1.0%	ATRX	4	0.3%	MSH2	2	0.2%	NTRK3	1	0.1%
SLX4	11	1.0%	CCND3	4	0.3%	mTOR	2	0.2%	PPP2R1A	1	0.1%
STK11	11	1.0%	ERBB2	4	0.3%	MYCN	2	0.2%	RICTOR	1	0.1%
NOTCH2	10	0.9%	KDR	4	0.3%	NTRK2	2	0.2%	TET2	1	0.1%
NOTCH3	10	0.9%	MRE11A	4	0.3%	PDGFRB	2	0.2%	UTR3	1	0.1%
SETD2	10	0.9%	NRAS	4	0.3%	PIK3CB	2	0.2%	AKT2	1	0.1%
GNAS	9	0.8%	RAD51D	4	0.3%	RAD51C	2	0.2%