Figure 5.

Pathology scores for various sections of the brain. (a) Global injury score from each pathology detected in brain sections (mean ± SEM) for all brain regions in swine with or without traumatic brain injury (TBI, SHAM, respectively) that received NVX-428 (NVX) or normal saline (NON) at 15 min after baseline and euthanized 360 min after baseline. (b) Break down from the various brain pathologies observed in different groups. (c) Specific regional injury scores for spongiosis and (d) ischemic/dead neurons (mean ± SEM) using Hematoxylin and Eosin (H&E) staining. EC/S = entorhinal cortex/subiculum. * p < 0.01 significance between SHAM and TBI groups.