Table 4.
Toxicity association with number of TSER-repeats. Associations were assessed in the 621 patients carrying only two or three repeat-element alleles. p-values from logistic regression models; 1 adjusted for cis-and carboplatin co-administration, sex, age, and DPYD-risk variants.
| Univariable | Multivariable 1 | |||||
|---|---|---|---|---|---|---|
| Outcome | OR | 95% CI | p-Value | OR | 95% CI | p-Value |
| Overall toxicity | 0.96 | 0.71–1.30 | 0.814 | 0.98 | 0.71–1.34 | 0.887 |
| Hematological toxicity | 0.73 | 0.49–1.08 | 0.119 | 0.75 | 0.49–1.13 | 0.174 |
| Gastrointestinal toxicity | 1.18 | 0.79–1.75 | 0.424 | 1.21 | 0.81–1.82 | 0.348 |
| Infection | 0.93 | 0.51–1.66 | 0.803 | 1.06 | 0.58–1.93 | 0.845 |
| Dermatological toxicity | 1.05 | 0.50–2.19 | 0.895 | 0.97 | 0.45–2.04 | 0.929 |