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Schematic diagram of cav-1-mediated selection of EV miRNAs via hnRNPA2B1. In the presence of noxious stimuli, such as oxidative stress, cav-1 Y14 is phosphorylated and results in conformational change of cav-1. This pY14-induced change exposes the CSD to bind with the hnRNPA2B1 RGG domain. The interaction of cav-1 and hnRNPA2B1 leads to the encapsulation of both hnRNPA2B1 and its bound miRNAs into the EVs along with cav-1.
