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. 2020 Oct 31;8(4):632. doi: 10.3390/vaccines8040632
AUC Area Under the Curve of plasma-concentrations versus time
BMI Body Mass Index
BSA Body Surface Area
BW Body Weight
CL Clearance
Cmax Maximum Concentration
Cmin Minimum Concentration
Cmin,ss Minimum Concentration at steady state
CTLA-4 Cytotoxic-T-Lymphocyte Antigen 4
DDI Drug-Drug Interaction
FDA Food and Drug Administration
FIH First-in-Human
ICI Immune Checkpoint Inhibitor
IIV Inter-Individual Variability
IL-2 Interleukin-2
irAEs immune related Adverse Events
MABEL Minimum Anticipated Biological Effect Level
mAbs Monoclonal Antibodies
MTD Maximum Tolerated Dose
NOAEL Non-Observed Adverse Effect Level
NSCLC Non-Small Cell Lung Cancer
OS Overall Survival
PBMCs Peripheral Blood Mononuclear Cells
PD Pharmacodynamics
PD-1 Programmed cell Death protein 1
PD-L1 Programmed Death Ligand 1
PDX Patient-Derived Xenografts
PFS Progression-Free Survival
PK Pharmacokinetics
QXW Every X weeks
RP2D Recommended Phase 2 Dose
TDM Therapeutic Drug Monitoring
TILs Tumor Infiltrating Lymphocytes
TKIs Tyrosine Kinase Inhibitors