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. 2020 Sep 2;15(1):833–840. doi: 10.1515/med-2020-0216

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© 2020 Yitong Yin et al., published by De Gruyter

This work is licensed under the Creative Commons Attribution 4.0 International License.

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The effect of IGF-1 siRNA on the cell viability, cell apoptosis, and the protein expression of Col I and Col III in HVFs obtained from POP patients. Control siRNA and IGF-1 siRNA were transfected into HVFs and then MTT, FCM, and Western blotting assay were used to detect the cell viability, cell apoptosis, and the protein expression of Col I and Col III. (a) The effect of IGF-1 siRNA on IGF-1 mRNA expression in HVFs. (b) The effect of IGF-1 siRNA on the cell viability of HVFs. (c and d) The effect of IGF-1 siRNA on the cell apoptosis of HVFs. (e) The effect of IGF-1 siRNA on the protein expression of Col I and Col III in HVFs. Data were reported as mean ± SD. **p < 0.01 vs control group.