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Saikosaponin A inhibited release of nucleus HMGB1, thus prevented the inflammatory effect. (a) Rats were sacrificed after MACO to detect the HMGB1 level. S10 and S100 groups restore the amount of HMGB1 as the Sham group, indicating that Saikosaponin A inhibited the release of HMGB1 from nucleus. (b and c) The serum levels of HMGB1 and LDH were detected. S10 and S100 groups reduced inflammation when compared with the model group, indicating that Saikosaponin A suppressed inflammation.
